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Guava (Psidium guajava L.) Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities.
Ruksiriwanich W, Khantham C, Muangsanguan A, Phimolsiripol Y, Barba FJ, Sringarm K, Rachtanapun P, Jantanasakulwong K, Jantrawut P, Chittasupho C, Chutoprapat R, Boonpisuttinant K, Sommano SR. Ruksiriwanich W, et al. Plants (Basel). 2022 Dec 14;11(24):3514. doi: 10.3390/plants11243514. Plants (Basel). 2022. PMID: 36559626 Free PMC article.
LC-MS analysis demonstrated that the main components of the ethanolic extract of guava leaves are phenolic substances, specifically catechin, gallic acid, and quercetin, which contribute to its scavenging and metal chelating abilities. The guava leaf extract substantially downreg …
LC-MS analysis demonstrated that the main components of the ethanolic extract of guava leaves are phenolic substances, specifically catechin …
Clinical characteristics and genetic expansion of 46,XY disorders of sex development children in a Chinese prospective study.
Tang Y, Chen Y, Wang J, Zhang Q, Wang Y, Xu Y, Li X, Wang J, Wang X. Tang Y, et al. Endocr Connect. 2023 Sep 4;12(10):e230029. doi: 10.1530/EC-23-0029. Print 2023 Oct 1. Endocr Connect. 2023. PMID: 37493574 Free PMC article.
Diagnosis and management strategy of disorders of sex development (DSD) are difficult and various due to heterogeneous phenotype and genotype. ...Novel candidate genes related to DSD (GHR (growth hormone receptor) and PHIP (pleckstrin homology domain-interacting pro …
Diagnosis and management strategy of disorders of sex development (DSD) are difficult and various due to heterogeneous phenotype and …
Correlation of androgen receptor and SRD5A2 gene mutations with pediatric hypospadias in 46, XY DSD children.
Fu XH, Zhang WQ, Qu XS. Fu XH, et al. Genet Mol Res. 2016 Mar 31;15(1):15018232. doi: 10.4238/gmr.15018232. Genet Mol Res. 2016. PMID: 27051040 Free article.
We performed an exploratory study by analyzing the correlation of 46, XY disorders of sex development (46, XY DSD) with androgen receptor (AR) and steroid 5alpha-reductase-2 (SRD5A2) gene mutations and a safety analysis of dihydrotestosterone (DHT) gel treatment for …
We performed an exploratory study by analyzing the correlation of 46, XY disorders of sex development (46, XY DSD) with androgen rece …
Steroid 5α-reductase 2 deficiency.
Mendonca BB, Batista RL, Domenice S, Costa EM, Arnhold IJ, Russell DW, Wilson JD. Mendonca BB, et al. J Steroid Biochem Mol Biol. 2016 Oct;163:206-11. doi: 10.1016/j.jsbmb.2016.05.020. Epub 2016 May 22. J Steroid Biochem Mol Biol. 2016. PMID: 27224879 Review.
Molecular investigation of mutations in androgen receptor and 5-alpha-reductase-2 genes in 46,XY Disorders of Sex Development with normal testicular development.
Ahmadifard M, Kajbafzadeh A, Panjeh-Shahi S, Vand-Rajabpour F, Ahmadi-Beni R, Arshadi H, Setoodeh A, Rostami P, Tavakkoly-Bazzaz J, Tabrizi M. Ahmadifard M, et al. Andrologia. 2019 Jun;51(5):e13250. doi: 10.1111/and.13250. Epub 2019 Feb 27. Andrologia. 2019. PMID: 30815925
In this study, we aimed to determine androgen receptor (AR) and SRD5A2 gene mutations in 45 patients characterised by 46,XY Disorders of Sex Differentiation (DSD) signs with normal testicular development referred to the Children's Medical Center from February 2015 t …
In this study, we aimed to determine androgen receptor (AR) and SRD5A2 gene mutations in 45 patients characterised by 46,XY Disord …
Dietary supplementation with perillartine ameliorates lipid metabolism disorder induced by a high-fat diet in broiler chickens.
Xiao Y, Jia M, Jiang T, Zhang C, Qi X, Sun Y, Gao J, Zhou L, Li Y. Xiao Y, et al. Biochem Biophys Res Commun. 2022 Oct 15;625:66-74. doi: 10.1016/j.bbrc.2022.07.116. Epub 2022 Aug 2. Biochem Biophys Res Commun. 2022. PMID: 35952609
Lipid metabolism disorders affect the growth and jeopardize the health of poultry, thus, decreasing economic benefits. ...Our results suggested that perillartine may be a promising, long-lasting therapeutic molecule for modulating lipid metabolism disorders i …
Lipid metabolism disorders affect the growth and jeopardize the health of poultry, thus, decreasing economic benefits. ...Our …
Effect of Ficus carica leaf extract on the gene expression of selected factors in HaCaT cells.
Turkoglu M, Pekmezci E, Kilic S, Dundar C, Sevinc H. Turkoglu M, et al. J Cosmet Dermatol. 2017 Dec;16(4):e54-e58. doi: 10.1111/jocd.12344. Epub 2017 Apr 22. J Cosmet Dermatol. 2017. PMID: 28432719
MATERIALS AND METHODS: The gene expression levels of vascular endothelial growth factor (VEGF), tumor necrosis factor-alpha (TNF-a), interleukin 1-alpha (IL-1a), and 5 alpha-reductase type II (SRD5A2) were tested in human keratinocyte cells (HaCaT) by RT-qPCR. ...CO …
MATERIALS AND METHODS: The gene expression levels of vascular endothelial growth factor (VEGF), tumor necrosis factor-alpha (TNF-a), …
Advances in genomic diagnosis of a large cohort of Egyptian patients with disorders of sex development.
Mazen I, Mekkawy M, Kamel A, Essawi M, Hassan H, Abdel-Hamid M, Amr K, Soliman H, El-Ruby M, Torky A, El Gammal M, Elaidy A, Bashamboo A, McElreavey K. Mazen I, et al. Am J Med Genet A. 2021 Jun;185(6):1666-1677. doi: 10.1002/ajmg.a.62129. Epub 2021 Mar 19. Am J Med Genet A. 2021. PMID: 33742552
Disorders/differences of sex development (DSD) comprise a group of congenital disorders that affect the genitourinary tract and usually involve the endocrine and reproductive system. The aim of this work was to identify genetic variants responsible for disorders …
Disorders/differences of sex development (DSD) comprise a group of congenital disorders that affect the genitourinary tract an …
Family History is Underestimated in Children with Isolated Hypospadias: A French Multicenter Report of 88 Families.
Ollivier M, Paris F, Philibert P, Garnier S, Coffy A, Fauconnet-Servant N, Haddad M, Guys JM, Reynaud R, Faure A, Merrot T, Wagner K, Bréaud J, Valla JS, Dobremez E, Gaspari L, Daures JP, Sultan C, Kalfa N. Ollivier M, et al. J Urol. 2018 Oct;200(4):890-894. doi: 10.1016/j.juro.2018.04.072. Epub 2018 Apr 30. J Urol. 2018. PMID: 29723568
PURPOSE: While familial forms of complex disorders/differences of sex development have been widely reported, data regarding isolated hypospadias are sparse and a family history is thought to be less frequent. ...Premature birth, assisted reproductive techniques, other cong …
PURPOSE: While familial forms of complex disorders/differences of sex development have been widely reported, data regarding isolated …
Late-onset vanishing testis-like syndrome in a 38,XX/38,XY agonadic pig (Sus scrofa).
Vilchis F, Mares L, Chávez B, Paredes A, Ramos L. Vilchis F, et al. Reprod Fertil Dev. 2020 Feb;32(3):284-291. doi: 10.1071/RD18514. Reprod Fertil Dev. 2020. PMID: 31679558
DNA studies excluded gene alterations in sex-determining region Y (SRY), dosage-sensitive sex reversal-congenital adrenal hypoplasia critical region on the X chromosome protein 1 (DAX1), SRY-related high mobility group-box gene 9 (SOX9), nuclear receptor subfamily 5, group a, mem …
DNA studies excluded gene alterations in sex-determining region Y (SRY), dosage-sensitive sex reversal-congenital adrenal hypoplasia critica …
16 results